I haven't done this myself, but I've heard about people doing it without trouble.
You specify that your window frames are wood, so that's not a problem. However, modern insulated (double-glazed) windows may have metal as part of the seal on the glass (it would be visible looking in through the glass). If you have this, make sure the ladder line doesn't run parallel to the frame on the inside or outside.
Twisting your ladder line also helps reduce radiation and coupling to nearby metal.
The second issue is interference with the speakers and other electronic equipment. In priority:
Make sure that you have a suitable balun either built in to, or in addition to, your antenna tuner. (I've heard rumors that some tuners with balanced outputs have baluns that aren't actually very effective.)
Ground the antenna tuner. If everything else is perfect, this is unnecessary, but it will help.
Finally, if you can separate equipment, do so. (Move that USB hub!) Try to have one side of the room for your digital signals and the other for your RF signals.